BIOL 237

Class Notes

 

Neurology

Functions of the nervous system:

1) Integration of body processes

2) Control of voluntary effectors (skeletal muscles), and mediation of voluntary reflexes.

3) Control of involuntary effectors (  smooth muscle, cardiac muscle, glands) and mediation of autonomic reflexes (heart rate, blood pressure, glandular secretion, etc.)

4) Response to stimuli

5) Responsible for conscious thought and perception, emotions, personality, the mind.

Structural Divisions of the nervous system:

1) Central Nervous System (CNS) - the brain and spinal cord.

2) Peripheral Nervous System (PNS) - the nerves, ganglia, receptors, etc.

Functional Divisions of the Nervous System:

1) The Voluntary Nervous System - (a.k.a. somatic division) control of willful control of effectors (skeletal muscles) and conscious perception. Mediates voluntary reflexes.

2) The Autonomic Nervous System - control of autonomic effectors - smooth muscles, cardiac muscle, glands. Responsible for "visceral" reflexes.

Nervous System Histology - cell types: (See Figure 11.3)

1) Neurons - the functional cells of the nervous system. See below.

2) Neuroglia (glial cells) - Long described as supporting cells of the nervous system, there is also a functional interdependence of neuroglial cells and neurons. [See Glioma Tumors]

a) astrocytes - these cells anchor neurons to blood vessels, regulate the micro-environment of neurons, and regulate transport of nutrients and wastes to and from neurons. [See Blood-Brain Barrier]

b) microglia - these cells are phagocytic to defend against pathogens. They may also monitor the condition of neurons.

c) ependymal cells - these cells line the fluid-filled cavities of the brain and spinal cord. They play a role in production, transport, and circulation of the cerebrospinal fluid.

d) oligodendrocyte - produce the myelin sheath in the CNS which insulates and protects axons.  [Multiple Sclerosis article]

e) Schwann cells - produce the myelin sheath in the PNS. The myelin sheath protects and insulates axons, maintains their micro-environment, and enables them to regenerate and re-establish connection with receptors or effectors. Enables saltatory conduction.  

f) satellite cells - surround cell bodies of neurons in ganglia. Their role is to maintain the micro-environment and provide insulation for the ganglion cells.

Neuron Structure:

In order to connect to other cells, receptors, and effectors, neurons have cytoplasmic extensions which attach to an enlarged area known as the cell body or cyton. Within the cell body is the nucleus and the neuron's biosynthetic machinery, the rough endoplasmic reticulum and the Golgi bodies. These organelles are so highly concentrated they can be visualized with a light microscope when stained with a specific technique. Called Nissl substance after the scientist who invented the staining technique, they manufacture the neurotransmitters which the neuron must secrete in large quantities. The neurotransmitter molecules are transported to the axon terminus by microfilaments and microtubules.

There are two basic types of cytoplasmic extensions: the dendrites and the axon. Dendrites are short branching processes which receive stimuli from receptors or other neurons. They can perform this function because they, like the exposed membrane of the cell body, possess chemically regulated ion gates (chemically gated ion channels) which respond to stimulation by neurotransmitters. So the dendrites increase the area on which a neuron can be stimulated and together with the rest of the membrane of the cell body constitute the neuron's receptive region (See Table 11.1).

A neuron will usually have only one axon, although it may branch extensively. The axon has voltage regulated ion gates (voltage gated ion channels) and therefor is responsible for carrying an impulse to another neuron or effector. The axon represents the neuron's conducting region. At the end of the axon, the axon terminus, is the secretory region where the neurotransmitters are released into the synapse.

The trigger zone is where the area with chemically regulated gates and the area with voltage regulated gates meet, usually at the junction of the axon and cell body, the axon hillock. In this area summation of depolarization and hyperpolarization (explained later) can produce enough depolarization to open the voltage regulated gates and produce an action potential.

Types of neurons based on structure:

The neuron pictured in Figure 11.4 and linked above is a multipolar neuron because it has many poles or processes, the dendrites and the axon. Multipolar neurons are found as motor neurons and interneurons(see below). There are also bipolar neurons with two processes, a dendrite and an axon, and unipolar neurons, which have only one process, classified as an axon. (See Table 11.1). Unipolar neurons are found as most of the body's sensory neurons. Their dendrites are the exposed branches connected to receptors, the axon carries the action potential in to the central nervous system.

Types of neurons based on function:

motor neurons - these carry a message to a muscle, gland, or other effector. They are said to be efferent, i.e. they carry the message away from the central nervous system.

sensory neurons - these carry a message in to the CNS. They are afferent, i.e. going toward the brain or spinal cord.

interneuron (a.k.a. association neuron, connecting neuron) - these neurons connect one neuron with another. For example in many reflexes interneurons connect the sensory neurons with the motor neurons.

A simple Reflex Arc illustrates how these three types of neurons might work together. We will discuss types of reflexes in a later section. The reflex shown has its center in the spinal cord our next topic. 

Spinal Cord and Peripheral Nerves

The spinal cord (See Figure 12.27) is the connection center for the reflexes as well as the afferent (sensory) and efferent (motor) pathways for most of the body below the head and neck. The spinal cord begins at the brainstem and ends at about the second lumbar vertebra. The sensory, motor, and interneurons discussed previously are found in specific parts of the spinal cord and nearby structures. Sensory neurons have their cell bodies in the spinal (dorsal root) ganglion. Their axons travel through the dorsal root into the gray matter of the cord. Within the gray matter are interneurons with which the sensory neurons may connect. Also located in the gray matter are the motor neurons whose axons travel out of the cord through the ventral root. The white matter surrounds the gray matter. It contains the spinal tracts which ascend and descend the spinal cord. Surrounding both the spinal cord and the brain are the meninges, a three layered covering of connective tissue. The dura mater is the tough outer layer. Beneath the dura is the arachnoid which is like a spider web in consistency. The arachnoid has abundant space within and beneath its thickened outer portion (the subarachnoid space) which contains cerebrospinal fluid, as does the space beneath the dura mater (subdural space). This cerebrospinal fluid supplies buoyancy for the spinal cord and brain to help provide shock absorption. The pia mater is a very thin layer which adheres tightly to the surface of the brain and spinal cord. It follows all contours and fissures (sulci) of the brain and cord.

An epidural injection of anesthetic, in childbirth for example, is placed immediately outside the dura mater. It penetrates slowly into the nearby nerve roots.

 

Terms:

ganglion - a collection of cell bodies located outside the Central Nervous System. The spinal ganglia or dorsal root ganglia contain the cell bodies of sensory neurons entering the cord at that region.

nerve - a group of fibers (axons) outside the CNS. The spinal nerves contain the fibers of the sensory and motor neurons. A nerve does not contain cell bodies. They are located in the ganglion (sensory) or in the gray matter (motor).

tract - a group of fibers inside the CNS. The spinal tracts carry information up or down the spinal cord, to or from the brain. Tracts within the brain carry information from one place to another within the brain. Tracts are always part of white matter.

gray matter - an area of unmyelinated neurons where cell bodies and synapses occur. In the spinal cord the synapses between sensory and motor and interneurons occurs in the gray matter. The cell bodies of the interneurons and motor neurons also are found in the gray matter.

white matter - an area of myelinated fiber tracts. Myelination in the CNS differs from that in nerves.

At 31 places along the spinal cord the dorsal and ventral roots come together to form spinal nerves (Figure 12.24). Spinal nerves contain both sensory and motor fibers, as do most nerves. Spinal nerves are given numbers which indicate the portion of the vertebral column in which they arise. There are 8 cervical (C1-C8), 12 thoracics (T1-T12), 5 lumbar (L1-L5), 5 sacral (S1-S5), and 1 coccygeal nerve. Nerve C1 arises between the cranium and atlas (1st cervical vertebra) and C8 arises between the 7th cervical and 1st thoracic vertebra. All the others arise below the respective vertebra or former vertebra in the case of the sacrum. Since the actual cord ends at the second lumbar vertebra, the later roots arise close together on the cord and travel downward to exit at the appropriate point. These nerve roots are called the cauda equina because of their resemblance to a horses tail.

Removing cerebrospinal fluid can be done by placing the needle in the sac of meninges below the conus medullaris where risk is minimal (See Figure 12.25).

The dermatomes are somatic or musculocutaneous areas served by fibers from specific spinal nerves. The map of the dermatomes is shown by Figure 13.11.This map is useful in diagnosing the origin of certain somatic pain, numbness, tingling etc. when these symptoms are caused by pressure or inflammation of the spinal cord or nerve roots. Referred pain is caused when the sensory fibers from an internal organ enter the spinal cord in the same root as fibers from a dermatome. The brain is poor at interpreting visceral pain and instead interprets it as pain from the somatic area of the dermatome. So pain in the heart is often interpreted as pain in the left arm or shoulder, pain in the diaphragm is interpreted as along the left clavicle and neck, and the "stitch in your side" you sometimes feel when running is pain in the liver as its vessels vasoconstrict. (See Figure 14.8)
Spinal nerves join together in plexuses. (See Figure 13.5) A plexus is an interconnection of fibers which form new combinations as the "named" or peripheral nerves. There are four voluntary plexuses (there are some autonomic plexuses which will be mentioned later): they are the cervical plexus, the brachial plexus, the lumbar plexus, and the sacral plexus. Each plexus gives rise to new combinations of fibers as the peripheral nerves. The nerves and plexuses you need to know are:

Cervical Plexus (See Figure 13.7, Table 13.3) - the phrenic nerve travels through the thorax to innervate the diaphragm.

Brachial Plexus (See Figure 13.8, Table 13.4) -

  • Axillary nerve - innervates the deltoid muscle and shoulder, along with the posterior aspect of the upper arm.
  • Musculocutaneous nerve - innervates anterior skin of upper arm and elbow flexors.
  • Radial nerve - innervates dorsal aspect of the arm and extensors of the elbow, wrist, and fingers, abduction of thumb.
  • Median nerve - innervates the middle elbow, wrist and finger flexors, adducts the thumb.
  • Ulnar nerve - innervates the medial aspect wrist and finger flexors.

Lumbar Plexus (See Figure 13.9, Table 13.5)

  • Femoral nerve: sensory from skin of anterior and medial thigh and medial leg and foot, hip and knee; motor to quadriceps muscles.
  • Obturator nerve: Motor to adductor magnus, longus and brevis, gracilis and obturator externus muscles; sensory for medial thigh, hip and knee.
  • Genitofemoral nerve: sensory from skin of genitalia and anterior thigh; motor to cremaster muscles in males.

Sacral Plexus (See Figure 13.10, Table 13.6)

 

Sciatic nerve

  • Tibial branch: Cutaneous branches – to skin of posterior leg and sole of foot; Motor to muscles of back of thigh, leg and foot: (except short head of biceps femoris), posterior part of adductor magnus, triceps surae, tibibialis posterior, popliteus, flexor digitorum longus, flexor hallucis longus, and intrinsic muscles of foot.
  • Fibular (Peroneal) Branch: Cutaneous – to skin and anterior surface of leg and dorsum of foot; Motor – to short head of biceps femoris, fibular (peroneal) muscles, tibialis anterior, extensor muscles of toes.

 

  • Superior gluteal nerve: gluteus medius and minimus, tensor fasciae latae.
  • Inferior gluteal nerve: gluteus maximus.
  • Pudendal nerve: skin and muscle of external genitalis and anal region.

 

Structure of a nerve:

A peripheral nerve is arranged much like a muscle in terms of its connective tissue. It has an outer covering which forms a sheath around the nerve, called the epineurium. Often a nerve will run together with an artery and vein and their connective coverings will merge. Nerve fibers, which are axons, organize into bundles known as fascicles with each fascicle surrounded by the perineurium. Between individual nerve fibers is an inner layer of endoneurium.

The myelin sheath in peripheral nerves consists of Schwann cells wrapped in many layers around the axon fibers. Not all fibers in a nerve will be myelinated, but most of the voluntary fibers are. The Schwann cells are portrayed as arranged along the axon like sausages on a string. (A more apt analogy would be like jelly rolls!) Gaps between the Schwann cells are called nodes of Ranvier. These nodes permit an impulse to travel faster because it doesn't need to depolarize each area of a membrane, just the nodes. This type of conduction is called saltatory conduction and means that impulses will travel faster in myelinated fibers than in unmyelinated ones.

The myelin sheath does several things:

1) It provides insulation to help prevent short circuiting between fibers.

2) The myelin sheath provides for faster conduction.

3) The myelin sheath provides for the possibility of repair of peripheral nerve fibers. Schwann cells help to maintain the micro-environments of the axons and their tunnel (the neurilemma tunnel) permits re-connection with an effector or receptor. (See below) CNS fibers, not having the same type of myelination accumulate scar tissue after damage, which prevents regeneration. [See Spinal Cord Repair]

Regeneration of a peripheral nerve fiber (See Figure 13.3) depends upon several things. First the damage must be far from the cell body. Anterograde degeneration destroys the axon distal to the point of damage. Retrograde degeneration causes the fiber to degenerate for a distance back toward the cell body. The amount of axoplasm lost determines whether the neuron can survive. Secondly the myelin sheath and its neurilemma tunnel must be intact. Chemicals such as the myelin proteins tend to inhibit regrowth, but macrophages will enter the damaged area and phagocytize these proteins and other debris. Schwann cells will proliferate and secrete growth stimulating factors and provide the chemical and physical needs necessary for growth and re-innervation by the axon.
The Spinal Tracts: (See Figure 12.30)

The white matter of the spinal cord contains tracts which travel up and down the cord. Many of these tracts travel to and from the brain to provide sensory input to the brain, or bring motor stimuli from the brain to control effectors. Ascending tracts, those which travel toward the brain are sensory, descending tracts are motor. Figure 12.30 shows the location of the major tracts in the spinal cord. For most the name will indicate if it is a motor or sensory tract. Most sensory tracts names begin with spino, indicating origin in the spinal cord, and their name will end with the part of the brain where the tract leads. For example the spinothalamic tract travels from the spinal cord to the thalamus. Tracts whose names begin with a part of the brain are motor. For example the corticospinal tract begins with fibers leaving the cerebral cortex and travels down toward motor neurons in the cord. [See Spinal Tract Pathways

White matter fibers are surrounded by oligodendrocytes which form the myelin sheath in CNS fibers. Diseases which destroy the myelin sheath lead to inability to control muscles, perceive stimuli etc. One such disease is multiple sclerosis, an autoimmune disorder in which your own lymphocytes attack the myelin proteins. [See Beta Interferon and Multiple Sclerosis].

Spinal Cord Injuries