Atherosclerosis
Fatty cholesterol-containing plaque along the lining of
arteries.
Due to damage to vessel walls, e.g. from hypertension.
Macrophages responding to this damage cause
inflammation and begin to accumulate abundant
cholesterol and LDL (Low Density Lipoproteins).
Smooth muscle cells grow into the lining and form the
framework of the plaque incorporating the fat-laden
macrophages.