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The carbohydrate portions of glycoproteins and glycolipids are
part of the glycocalyx or "sugar coating" many cells have.
This layer is part of the recognition system by which cells are identified by
other cells such as those of the immune system, and it functions as a
protective coating for some cells. Proteoglycans are molecules with a
core protein and attached glycosaminoglycans (GAGs). See [The
Structure of a Proteoglycan Complex]. GAGs are composed of aminated
(containing amine groups) and sulfated (containing sulfate groups)
disaccharides and are important to the structure and function of many tissues
and the extracellular matrix (ECM). [See histology ].
Glycosaminoglycans include hyaluronic acid, heparan sulfate (gives rise to
heparin), keratan sulfate (gives rise to keratin), glucosamine, and
chondroitin sulfate. Other glycoproteins include collagen, elastin,
and reticular fibers.
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